Andrew Thomas DeWan

A higher polygenic score for peripheral artery disease is associated with younger age at surgery among patients undergoing revascularization

The paper finds a higher polygenic score for PAD is linked to younger age at surgery, replicated in UK Biobank.

LDSC regression-based heritability estimates can be biased when summary statistics are obtained from meta-analysis or imputed variants

The paper shows that LDSC regression can underestimate heritability when using meta-analysis or imputed variant summary statistics instead of genotyped data.

Leveraging cis- and trans-variants to improve protein expression level prediction for proteome-wide association studies

The paper introduces TransCisPredict to predict protein expression using cis- and trans-variants, improving proteome-wide association study power for type 2 diabetes.

LANTERN: Leveraging Local Ancestry Tracts to Enhance Rare-Variant Aggregate Association Testing

LANTERN improves rare-variant association testing in admixed populations by incorporating local ancestry information, identifying ancestry-specific associations in a cohort of African Americans.

Association of genetic variants in the autophagy gene ATG4B with asthma

The paper identifies genetic variants in ATG4B associated with asthma using GWAS data from the UK Biobank, showing significant associations in the discovery dataset and nominal replication.

Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits

This paper identifies shared genetic and neuroimmune mechanisms linking type 1 diabetes with neurocognitive traits through genome-wide association and single-cell epigenomic analyses.

Leveraging pleiotropy to improve genetic risk prediction across diseases

This paper improves genetic risk prediction across diseases by developing multi-trait polygenic scores that integrate GWAS data and show better performance than single-trait scores.

Shared genetic factors between lung function and asthma by age at onset

This study identifies shared genetic factors between asthma and lung function that vary by age-at-onset, highlighting distinct mechanisms for early-onset asthma.

PAD-associated genetic variants are more strongly associated with surgical intervention than premature onset

This study identifies PAD-associated SNPs with stronger associations with surgical intervention than premature onset using UK Biobank data.

Identification of multi-omic pleiotropy factors for peripheral artery disease

This paper identifies multi-omic pleiotropy factors for peripheral artery disease by analyzing genetic, transcriptomic, and proteomic data across PAD, T2D, and CAD.

Rare-variant aggregate association analysis using imputed data is a powerful approach.

The paper evaluates the power of rare variant aggregate association analysis using imputed data and finds that imputation can detect significant associations even for ultra-rare variants, though with reduced power compared to sequence data.

A framework for studying multi-omic risk factors and their interplay: application to coronary artery disease

The paper presents a framework to analyze multi-omic risk factors for coronary artery disease using TWAS and PWAS, identifying 10 genes with shared associations and colocalized eQTLs and pQTLs.

LDER-GE estimates phenotypic variance component of gene-environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information

Genome-wide transethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia

This study identifies five novel genetic loci associated with childhood acute lymphoblastic leukemia through a trans-ethnic meta-analysis across four ethnic groups.

Genetic Determinants of Blood Cell Traits Influence Susceptibility to Childhood Acute Lymphoblastic Leukemia

This study identifies genetic variants influencing blood cell traits linked to increased susceptibility to childhood acute lymphoblastic leukemia.

Genome-wide association study of skin and soft tissue infection susceptibility

This paper conducts a genome-wide association study (GWAS) of skin and soft tissue infections (SSTIs), identifies genetic loci, and shows that BMI and smoking increase SSTI risk.

Proteinarium: Multi-Sample Protein-Protein Interaction Analysis and Visualization Tool

Proteinarium analyzes and visualizes protein-protein interaction networks across multiple samples to identify disease-related gene clusters.