The evolution of robustness and fragility during long-term bacterial adaptation
Doha Chihoub, Coralie Pintard, Richard E. Lenski, Olivier Tenaillon, Alejandro Couce
This study shows that during long-term bacterial adaptation, fitness effects of mutations become less severe, but pleiotropic effects in new environments become more severe, indicating trade-offs between robustness and fragility.
Proceedings of the National Academy of Sciences · Apr 15, 2025Peer-reviewedEvolutionary Biology