BioinformaticsbioRxivPreprint
EvoSeq-ML: Advancing Data-Centric Machine Learning with Evolutionary-Informed Protein Sequence Representation and Generation
Mehrsa Mardikoraem, Nathaniel Pascual, Joelle N. Eaves…·Daniel Woldring
This paper evaluates an ancestral sequence reconstruction-informed data augmentation strategy for improving protein sequence generation and representation learning, showing improved thermostability in generated variants.
DOI 10.1101/2024.10.02.616302