Author

Charles Bonner Harris

University of CambridgeORCID 0009-0003-5897-0704Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Hao ZhangiD· 1 shared Michele VendruscoloiD· 1 shared Píetro LióiD· 1 shared Robert I. HorneiD· 1 shared Z. Faidon BrotzakisiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperBiophysics

Hao ZhangORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintAug 16, 2025

Structure-based Generation of a Secondary Nucleation Inhibitor in alpha-Synuclein Aggregation Using a Conditional Diffusion Model

Hao Zhang, Robert I. Horne, Z. Faidon Brotzakis…·Michele Vendruscolo

The paper uses a conditional diffusion model to design a small molecule inhibitor of secondary nucleation in alpha-synuclein aggregation, showing it effectively inhibits fibril proliferation.

DOI 10.1101/2025.08.16.670694

deep learningdiffusion model

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