Author

Charles Broadbent

ORCID 0009-0003-6033-546XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:dimensionality reduction· 1 Approach:matrix factorization· 1 Organism:mouse· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Quoc Nguyen· 1 shared Rui KuangiD· 1 shared Tianci Song· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBioinformatics

Quoc Nguyen

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1 paper

Recent·Most cited

BioinformaticsPLoS Computational BiologyPeer-reviewedMar 13, 2026

CTFacTomo: Reconstructing 3D Spatial Structures of RNA Tomography Transcriptomes by Collapsed Tensor Factorization

Tianci Song, Quoc Nguyen, Charles Broadbent, Rui Kuang

CTFacTomo reconstructs 3D spatial gene expressions from RNA tomography data using tensor factorization and regularization, outperforming benchmarks on zebrafish and mouse datasets.

DOI 10.1371/journal.pcbi.1013457

zebrafishmouse

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