Author

Lyuwei Wang

University of MissouriORCID 0009-0003-7678-4972Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Assay:ChIP-seq· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:protein structure· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Jianlin Jack ChengiD· 2 shared Ping Liu· 1 shared Shreya Basnet· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersBioinformatics

Jianlin Jack ChengORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintSep 23, 2026

Leakage-controlled benchmarking reveals generalization limits of deep learning for protein-ligand binding affinity prediction

Lyuwei Wang, Jianlin Jack Cheng

This paper introduces PLABench, a benchmarking framework for protein-ligand binding affinity prediction, revealing that structural input and training scale alone do not ensure cross-target generalization.

DOI 10.64898/2026.09.17.752433

protein structuredeep learning

𝕏 PostBluesky

BioinformaticsbioRxivPreprintApr 15, 2026

TFBindFormer: A Cross-Attention Transformer for Transcription Factor-DNA Binding Prediction

Ping Liu, Lyuwei Wang, Shreya Basnet, Jianlin Jack Cheng

TFBindFormer improves TF-DNA binding prediction by integrating DNA and TF protein features using cross-attention, outperforming DNA-only models.

DOI 10.64898/2026.04.09.717563

ChIP-seqtransformer / foundation model

𝕏 PostBluesky