Author

Aaron Alvarez

University of CincinnatiORCID 0009-0003-9036-9847Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1

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Aleksey PorolloiD· 1 shared Jichao CheniD· 1 shared Om JadhaviD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBioinformatics

Aleksey PorolloORCID

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1 paper

Recent·Most cited

BioinformaticsBioinformaticsPeer-reviewedJun 13, 2026

SPPIDER-seq: Sequence-based partner-aware predictor of protein-protein interaction sites

Aleksey Porollo, Om Jadhav, Aaron Alvarez, Jichao Chen

SPPIDER-seq predicts protein-protein interaction sites by considering partner-specific context, outperforming AlphaFold3 on disordered interfaces and revealing partner-specific patterns in TP53 interactions.

DOI 10.1093/bioinformatics/btag388

protein sequencedeep learning

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