Aleksey Porollo

SPPIDER-seq: Sequence-based partner-aware predictor of protein-protein interaction sites

SPPIDER-seq predicts protein-protein interaction sites by considering partner-specific context, outperforming AlphaFold3 on disordered interfaces and revealing partner-specific patterns in TP53 interactions.

BPabZIP, a new bZIP protein motif that promotes binding near, and displacement of, nucleosomes

The paper identifies a new bZIP protein motif, BPabZIP, that facilitates nucleosome displacement and binding near nucleosomes in human cells.

Single-Cell RNA Sequencing Defines Developmental Progression and Reproductive Transitions of Pneumocystis carinii

This study uses scRNA-seq to map the life cycle of Pneumocystis carinii, identifying transcriptional states associated with developmental stages and reproductive transitions.

Role of Forkhead box F1 in the Pathobiology of Pulmonary Arterial Hypertension

The paper identifies rare FOXF1 missense variants in PAH patients, shows dysregulated FOXF1 expression in PAH lungs, and identifies downstream targets linked to PAH pathogenesis.