Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice
Laura Sophie Kremer, Guanbin Gao, Giovanni Rigoni, Roberta Filograna, Mara Mennuni, Rolf Wibom, Ákos Végvári, Camilla Koolmeister, Nils‐Göran Larsson
This study investigates tissue-specific effects of TFAM and mtDNA copy number manipulation in mtDNA mutator mice, revealing both beneficial and detrimental outcomes depending on the tissue.
eLife · Jun 30, 2025Peer-reviewedGenetics