Ákos Végvári

This study uses multi-omics to uncover Gardnerella genomic features linked to biofilm formation and interspecies interactions in the vaginal microbiome, identifying potential therapeutic targets for bacterial vaginosis.

This study identifies the mitochondrial transaminase GOT2 as a metabolic dependency of JEV and a potential host-directed antiviral target through integrated transcriptomics and proteomics analyses.

This study identifies SET7 as a driver of endothelial dysfunction in cardiometabolic disorders by altering mRNA splicing and eNOS-CaM interaction.

This study establishes quality control standards for single-cell proteomics through inter-laboratory benchmarking, identifying software and technical factors affecting data reliability.

This study shows that mitoSAM-dependent lipoylation is essential for postnatal heart development by enabling metabolic remodeling from glycolysis to oxidative phosphorylation.

This study shows that ISG15-USP18 signaling limits viperin-dependent metabolic antiviral restriction by stabilizing USP18 and reducing viperin expression, thereby inhibiting viral replication.

The paper introduces KISSE, a statistical framework for species identification using bone collagen tandem mass spectrometry data, which provides species identification and probability estimates.

This study investigates tissue-specific effects of TFAM and mtDNA copy number manipulation in mtDNA mutator mice, revealing both beneficial and detrimental outcomes depending on the tissue.

This study examines how human ovarian cortical and medullary cells respond to acute X-ray exposure, finding transcriptomic shifts and impaired cell-cell adhesion.

The paper identifies metabolic reprogramming in HIV-treated individuals that impairs monocyte migration and promotes M2-like macrophage polarization, enhancing HIV susceptibility.

This study develops and characterizes 3D models of human ovarian primary cells using Biosilk scaffolds, showing they maintain key cell types and form a hypoxic core.

This study characterizes the HLA-DR immunopeptidome in lung cells of early RA patients and healthy smokers, finding that HLA-DR genotype drives the immunopeptidome more than RA status or sex.

This study analyzes miRNAs and proteins in exhaled particles to explore their role in respiratory diseases using non-invasive PExA sampling.

This study applies a multimodal lifestyle intervention in mice to improve cognition and synaptic plasticity, showing effects comparable to pharmacological interventions.

The paper introduces GAPPIS, a method to recover molecular weight information from shotgun proteomics, identifying novel caspase 3 substrates in apoptotic cells.

The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.

The paper investigates tissue-specific metabolic reprogramming and gut dysbiosis in hamsters infected with SARS-CoV-2 variants, revealing differences in viremia, metabolic responses, and microbiota composition between delta and omicron variants.