Chemically induced cell plasticity enables the generation of high-fidelity embryo model
Huanhuan Li, Jiahui Huang, Wei Guan, Jinyi Wu, Haiping Luo, Litao Chang, Haiyong Zhao, Chuanxin Chen, Yake Gao, Jian Zhang, José C. R. Silva
This paper develops a chemical-only method to generate high-fidelity embryo models by inducing cell plasticity in stem cells, resulting in embryo-like structures that recapitulate early developmental stages.
bioRxiv · Jun 20, 2024 · PreprintCell Biology