José Silva

This paper develops a chemical-only method to generate high-fidelity embryo models by inducing cell plasticity in stem cells, resulting in embryo-like structures that recapitulate early developmental stages.

The paper identifies a genetic circuitry where OCT4 activates an antisense lncRNA that represses Suv39h1, linking H3K9 methylation levels to pluripotency in mouse ES cells.

This study uses an auxin-degron system to show that Oct4 depletion reduces pluripotency factor expression and enhances Nanog genome binding while decreasing H3K27ac marks.

This study shows that low Sox2 expression in naive pluripotent stem cells enhances their developmental plasticity without impairing neuroectoderm differentiation.

This study identifies OCT4's role in maintaining pluripotency through metabolic regulation and Stat3 signaling in mouse embryos.

The paper identifies TCF4 and ID3 as key transcription factors driving mammary epithelial stem cell differentiation through single-cell RNA sequencing analysis.

The paper identifies Brca1, Bard1, and Wdr5 as factors linking DNA damage response to MET during reprogramming, using siRNA screening and colony morphology analysis.