Developmental BiologybioRxivPreprint
Time-dependent BMP4 signaling directs lineage specification in human mesoderm
Wei Zhao, Filip J. Wymeersch, Minoru Takasato
This study shows that timed BMP4 signaling directs mesoderm lineage specification in human pluripotent stem cells, with early BMP4 promoting lateral plate mesoderm and late BMP4 promoting intermediate mesoderm.