Minoru Takasato

Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors

The paper identifies two thresholds of Brachyury expression in NMPs that determine lineage potential and axis-forming ability in vitro.

Time-dependent BMP4 signaling directs lineage specification in human mesoderm

This study shows that timed BMP4 signaling directs mesoderm lineage specification in human pluripotent stem cells, with early BMP4 promoting lateral plate mesoderm and late BMP4 promoting intermediate mesoderm.

Identification of three distinct cell populations for urate excretion in human kidney

The paper identifies three distinct cell populations in human kidney tubules involved in urate handling, showing heterogeneity in transporter expression and function.

Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor

This study identifies TBXT's role in early posterior regionalisation of human neural crest cells through chromatin remodelling and WNT signalling.

Reprogramming Epiblast Stem Cells into Pre-Implantation Blastocyst Cell-like Cells

The paper reprograms epiblast stem cells into blastocyst-like cells using single-cell RNA sequencing and identifies three major cell fate populations.

Transcriptional evaluation of the developmental accuracy, reproducibility and robustness of kidney organoids derived from human pluripotent stem cells