Author

Nuo Jia

Jilin UniversityORCID 0009-0004-1700-9535Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1

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Hao ZhangiD· 1 shared Junqi WuiD· 1 shared Liyan DongiD· 1 shared Longyu LiiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBioinformatics

Hao ZhangORCID

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1 paper

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BioinformaticsbioRxivPreprintFeb 8, 2026

Decoupling Structure and Property in Discrete Protein Diffusion: Alignment Dynamics and Collapse Mechanisms

Junqi Wu, Liyan Dong, Nuo Jia…·Hao Zhang

This paper investigates the temporal dynamics of discrete protein diffusion models, revealing a decoupling between structural alignment and property optimization, and identifies a structural collapse regime due to Coulombic repulsion.

DOI 10.64898/2026.02.05.701726

protein sequencedeep learning

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