Discovery of circulating cell-free DNA 5hmC biomarkers for peritoneal metastasis in colorectal and appendiceal cancer
Yuri Malina, Lu Gao, Ankit Dhiman, Diana C. West-Szymanski, Yaniv Berger, Xiaolong Cui, Zhou Zhang, Marco A. Rivas, Urszula Dougherty, Chang Ye, Akushika Kwesi, Zifeng Deng, Biren Reddy, Hunter D. D. Witmer, Phillip J. Hsu, , Kiran Kalyan Turaga
This study uses 5hmC-Seal technology to detect 5hmC signatures in cfDNA from plasma, identifying peritoneal metastases in CRC and AA with high sensitivity but moderate specificity.
bioRxiv · Sep 18, 2025 · PreprintCancer Biology