Xiaolong Cui

Ultra-sensitive Mapping of Cell-free DNA-derived Methylomes Reveals Brain-specific Epigenetic Alterations Implicated in Alzheimer Disease

The paper demonstrates the feasibility of detecting methylation differences in serum-derived cell-free DNA between Alzheimer's disease and non-AD controls using LABS, linking these changes to brain-specific epigenetic alterations in AD.

Discovery of circulating cell-free DNA 5hmC biomarkers for peritoneal metastasis in colorectal and appendiceal cancer

This study uses 5hmC-Seal technology to detect 5hmC signatures in cfDNA from plasma, identifying peritoneal metastases in CRC and AA with high sensitivity but moderate specificity.

Machine learning identifies cell-free DNA 5-hydroxymethylation biomarkers that detect occult colorectal cancer in PLCO Screening Trial subjects

This study uses machine learning to identify 5-hydroxymethylation biomarkers in cell-free DNA that can detect occult colorectal cancer up to 36 months before diagnosis.

Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome

This paper introduces DR-6mA-seq, a method to detect 6mA at single-base resolution in mammalian genomes, finding low abundance in most tissues but distinct sites in mouse testis and glioblastoma cells.