MicrobiologyCell ReportsPeer-reviewed
Molecular basis of sarbecovirus evolution and receptor tropism in natural hosts, potential intermediate hosts, and humans
Yusuke Kosugi, Kanata Matsumoto, Spyros Lytras…·Kei Sato
This study investigates the ACE2 tropism of sarbecoviruses across 17 mammals using pseudovirus assays, structural analysis, and phylogenetics to identify genetic factors influencing host range.