BiochemistryJournal of Biological ChemistryPeer-reviewed
The nucleotide exchange factor, GrpE, modulates substrate affinity by interaction of its N-terminal tails with the DnaK substrate-binding domain.
Akshitha Maqtedar, María-Agustina Rossi, Eugenia M. Clérico…·Lila M. Gierasch
This paper investigates how GrpE modulates DnaK's substrate affinity through interactions between GrpE's N-terminal tails and DnaK's SBD, revealing a temperature-dependent mechanism.
DOI 10.1016/j.jbc.2026.111176