Bethan Mallabar-Rimmer

This study identifies DNA methylation differences between microsatellite stable and microsatellite instable colorectal cancers, revealing MLH1-independent markers of mismatch repair deficiency and the impact of anatomical location.

The paper re-annotates the EPICv2 methylation array manifest to improve compatibility with previous versions and provide more comprehensive annotations for DNA methylation data.

This study identifies epigenetic changes and accelerated ageing in multifocal small intestinal neuroendocrine tumours, revealing altered metabolic gene regulation and tumour-specific methylation patterns.

This paper develops a polygenic risk score model to predict colorectal cancer risk in symptomatic patients using UK Biobank data, achieving high predictive accuracy.

The paper examines how family history affects cancer penetrance in individuals with pathogenic variants, finding higher risks with family history for BRCA1/2 and Lynch syndrome.