BiochemistrybioRxivPreprint
Loss of PTPRB function remodels VEGFR1 activation in tumors overexpressing the receptor tyrosine kinase
Rahul Das, S. Ghosh, Abheek Pathak…·Saptarshi Pyne
The paper investigates how loss of PTPRB function affects VEGFR1 activation in tumors, finding that PTPRB deficiency leads to ligand-independent dimerization and sustained phosphorylation of VEGFR1, promoting tumor vascularization.