Promoter DNA Methylation Epigenetically Regulates the Tumor-Suppressor Function of the miR-379/656 (C14MC) Cluster in Hepatocellular Carcinoma
Shreyas Hulusemane Karunakara, Shama Prasada Kabekkodu, Akila Prashant, Rohit Mehtani, Prashant M. Vishwanath, Gopalakrishna Ramaswamy, Prasanna K. Santhekadur
This study shows that the miR-379/656 cluster is a tumor suppressor in HCC regulated by promoter DNA methylation, with potential for early diagnosis and prognosis.
bioRxiv · Dec 4, 2025 · PreprintCancer Biology