De Novo Non-Canonical Nanopore Basecalling Enables Private Communication using Heavily-modified DNA Data at Single-Molecule Level
Qingyuan Fan, Xuyang Zhao, Junyao Li, Ronghui Liu, Ming Liu, Qishun Feng, Yanping Long, Yang Fu, Jixian Zhai, Qing Pan, Yi Li
DeepSME enables private DNA-based communication by decrypting heavily modified DNA using nanopore sequencing and deep learning, achieving high precision and recall.
Nature Communications · May 2, 2025Peer-reviewedBioinformatics