Gaming the cancer-immunity cycle by synchronizing the dose schedules
Saeedeh Mahmoodifar, K. Stuckey, Paul K. Newton
The paper introduces a mathematical model of the cancer-immunity cycle to optimize chemotherapy and immunotherapy dosing schedules by synchronizing them with the cycle's period, showing that optimized timing can improve efficacy with lower doses.
Proceedings of the National Academy of Sciences · Aug 8, 2025Peer-reviewedSystems Biology