A validated neuronal SH-SY5Y platform reveals critical experimental variables for reproducible Aβ 1-42 self-assembly neurotoxicity assessment
Anne-Cécile van Baelen, Clement Poteaux, Philippe Robin, Xavier Iturrioz, Steven Panek, Norbert Sewald, Denis Servent, Nicolò Tonali
The paper establishes a neuronal SH-SY5Y model to assess Aβ1-42 self-assembly neurotoxicity, showing that toxicity depends on aggregation state, cell differentiation, and assay type.
bioRxiv · Jul 17, 2026 · PreprintNeuroscience