Norbert Sewald

The paper establishes a neuronal SH-SY5Y model to assess Aβ1-42 self-assembly neurotoxicity, showing that toxicity depends on aggregation state, cell differentiation, and assay type.

This paper designs a synthetic peptide mimicking Hsp90-Tau interaction to inhibit Tau aggregation and restore its microtubule binding, showing efficacy in vitro and in cells.