Florian Sicklinger

This study identifies a cardio-intestinal innate immune circuit driven by tricuspid valve regurgitation that promotes heart failure through IL-6-mediated myocardial fibrosis and dysfunction.

This study compares two myocardial infarction models, showing the intact-chest model better reflects human immune responses and identifies immature neutrophils as contributors to cardiac dysfunction.

This study identifies RUNX1 as a key regulator of cardiac recovery by reprogramming macrophages, showing that its inhibition promotes heart function recovery in a chronic heart failure model.

This study maps acute murine myocardial infarction with subcellular resolution, identifying a novel endocardial route of immune cell infiltration and vWF as a key mediator.

This study shows that temporarily inhibiting protein translation after heart attack reduces inflammation and improves long-term heart function by targeting the mTORC1-4EBP1-eIF4F pathway.