BiochemistryPlant and Cell PhysiologyPeer-reviewed
CRISPR/Cas9-mediated genome editing reveals the involvement of a polyphenol oxidase in the shikonin-specific biosynthesis in Lithospermum erythrorhizon
Kohei Nakanishi, Yuki Takano, Kyoko Yamamoto…·Kazufumi Yazaki
The paper uses CRISPR/Cas9 to edit the LePPO1 gene in Lithospermum erythrorhizon, showing it is involved in shikonin biosynthesis and explains the role of copper in the process.