Author

Madison E Lapine

Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA;ORCID 0009-0004-6885-8940Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam SiepeliD· 1 shared Alexander GroshiD· 1 shared Alexandra J KiedrowskiiD· 1 shared Claire ReganiD· 1 shared Deena M NetziD· 1 shared Dominic PrussiD· 1 shared Hannah V MeyeriD· 1 shared Harvey I PassiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Adam SiepelORCID

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1 paper

Recent·Most cited

Gene regulatory logic underlying the differentiation of mixed lineages in human thymic epithelial cells

Rishvanth K Prabakar, Sarah R Chapin, Yong Lin, Stephen J Staklinski, Deena M Netz, Madison E Lapine, Dominic Pruss, Todor Cvetanovic, Salome L Carcy, Joshua Torres, Alexander Grosh, Alexandra J Kiedrowski, Harvey I Pass, Ralph Mosca, Claire Regan, , Hannah V Meyer

The paper identifies 17 human thymic epithelial cell subsets using single-cell data and shows they share a common ancestor and regulatory logic, with some conservation in mice.

bioRxiv · Nov 2, 2026 · PreprintImmunology