Rishvanth K. Prabakar

The paper introduces gcat and its_a_scam, modular tools for single cell genomic data processing and quality control, showing they produce results comparable to proprietary pipelines.

The paper identifies 17 human thymic epithelial cell subsets using single-cell data and shows they share a common ancestor and regulatory logic, with some conservation in mice.

The paper shows that sparse, random sampling of self peptides in the thymus is sufficient for T cell tolerance to most peripheral self peptides, supported by experimental data and machine learning analysis.

This study shows pancreatic cancer cells secrete keratin-19 (KRT19) without a signal peptide by entering the ER via its head domain and through secretory autophagy, enabling CXCL12 capture to exclude T cells.

The paper identifies polyploid cancer cells as markers of chemotherapy resistance and recurrence in prostate cancer, linking them to poorer survival outcomes.

GeTMoR enables simultaneous genomic, transcriptomic, and morphological profiling of rare single cells, linking phenotype to molecular features.

SMURF-seq enables fast, multiplexed copy number profiling using long-read sequencers by ligating short DNA molecules into long reads.