Gasdermin E couples mitochondrial stress to STING-driven neuronal pyroptosis during Chandipura virus encephalitis
Nripa Kumari, Sourav Dutta, Akasmika Priyadarsani, Joyanta Biswas, Shubhangi Roy, Suman Samanta, Semanti Chakraborty, Jyotirmoyee Roy, Anirban Basu, Debanjan Mukhopadhyay, Abhik Saha, Piyali Mukherjee
This study identifies a mitochondria-GSDME-STING axis that links early immune evasion to neuroinflammation during Chandipura virus infection, revealing a mechanism of inflammatory neuronal death.
bioRxiv · Sep 27, 2026 · PreprintImmunology