Xiaoke K. Chen

This study shows that preventing cryptic splicing of UNC13A and other TDP-43 targets can preserve memory and reduce neuron loss in a TDP-43 knockout mouse model.

This study shows that TDP-43 dysfunction accelerates tauopathy, which primes co-filament assembly and dysfunction of TDP-43, exacerbating neuron loss in AD-LATE.

This paper shows that TDP-43 loss-of-function worsens tauopathy in a mouse model by increasing caspase 3-mediated tau cleavage in vulnerable neurons, leading to greater brain atrophy.