Tong Li

This study shows that TDP-43 dysfunction accelerates tauopathy, which primes co-filament assembly and dysfunction of TDP-43, exacerbating neuron loss in AD-LATE.

The paper shows CDCA7A and CDCA7B maintain CG methylation in centromeric heterochromatin by remodeling H1-containing nucleosomes, with H1 having an inhibitory role.

This paper shows that TDP-43 loss-of-function worsens tauopathy in a mouse model by increasing caspase 3-mediated tau cleavage in vulnerable neurons, leading to greater brain atrophy.

The paper identifies stage-specific microglia subtypes in Alzheimer's disease using single-cell RNA-sequencing, showing both amyloid-beta and tau pathologies are required for their induction.