Innate Immune Remodeling Drives Therapy Resistance via Macrophage-NK Cell Crosstalk.
Chia‐Hsin Hsu, Keng‐Jung Lee, Jingyi Chen, Leanne R. Donahue, Jianping Lin, Danielle Kacaj, Zhong‐Yin Zhang, Andrew C. White
This study identifies macrophage-driven NK cell infiltration during tumor regression and subsequent exclusion during residual disease as key factors in therapy resistance, highlighting macrophage-NK cell crosstalk as a therapeutic target.
bioRxiv · Jul 22, 2025 · PreprintCancer Biology