Zhong‐Yin Zhang

The paper develops a chemoselective bioconjugation method to detect and analyze NEylation, revealing it as a widespread PTM affecting protein function in cells.

This study shows that deleting Shp1 and Shp2 in mice impairs megakaryopoiesis and thrombopoiesis, leading to macrothrombocytopenia and reduced platelet function.

This paper introduces AiPP, an AI-based platform for predicting ligandable sites in the human proteome, and demonstrates its application in discovering covalent inhibitors for PTPN6.

This study identifies macrophage-driven NK cell infiltration during tumor regression and subsequent exclusion during residual disease as key factors in therapy resistance, highlighting macrophage-NK cell crosstalk as a therapeutic target.

The paper identifies D2HG and L2HG-induced O-2-hydroxyglutarylation with chiral specificity, revealing inhibitory effects on kinases MRCKA and SLK.

This paper introduces a correlative imaging method using nano-DESI MSI to map lipids, metabolites, peptides, and proteins in single tissue sections, revealing molecular gradients in mouse pancreatic tissue.