Pharmacology & ToxicologybioRxivPreprint
Report on pre-validation of an animal-free alternative method (NAM) for regulatory safety testing: InfiniteLungDT, an in-vitro-learned digital twin for the prediction of material-triggered chronic neutrophilic lung inflammation
Iztok Urbančič, Tilen Koklič, Hana Kokot…·Janez Štrancar
The paper pre-validates an animal-free method, InfiniteLungDT, which predicts chronic neutrophilic lung inflammation using in vitro data, achieving high accuracy in LOAEL determination.