Coordination of transcription-coupled repair and repair-independent release of stalled RNA polymerase II in response to transcription-blocking lesions
Yongchang Zhu, Xiping Zhang, Meng Gao, Yanchao Huang, Yuanqing Tan, Avital Parnas, Sizhong Wu, Delin Zhan, Sheera Adar, Jinchuan Hu
This study shows that lesion-stalled RNA polymerase II can be evicted by the p97-proteasome pathway independently of repair, and both processes require CSA and ubiquitination.
bioRxiv · Jul 7, 2024 · PreprintMolecular Biology