Sheera Adar

A Novel Cisplatin-Based Prodrug Inhibits Lysine Deacetylases, Suppresses Nucleotide Excision Repair, and Overcomes Resistance

This study develops a novel cisplatin-based prodrug that inhibits lysine deacetylases and suppresses nucleotide excision repair, enhancing cisplatin's cytotoxicity and overcoming resistance.

Coordination of transcription-coupled repair and repair-independent release of stalled RNA polymerase II in response to transcription-blocking lesions

This study shows that lesion-stalled RNA polymerase II can be evicted by the p97-proteasome pathway independently of repair, and both processes require CSA and ubiquitination.

GENI: a web server to identify gene set enrichments in tumor samples

GENI is a web tool that identifies gene set enrichments in TCGA tumor data, simplifying analysis for non-experts by evaluating gene expression in the context of the whole transcriptome.

Cancer mutational processes vary in their association with replication timing and chromatin accessibility

The paper analyzes mutational signatures in tumors to determine their association with replication timing and chromatin accessibility, finding signature-specific associations and clinical relevance of SBS16 in liver cancer.

The sequential and cooperative action of CSB, CSA and UVSSA targets the TFIIH complex to DNA damage-stalled RNA polymerase II

This study defines the sequential and cooperative assembly mechanism of the TCR complex and reveals how TFIIH is recruited to DNA damage-stalled RNAPIIo.