Embryonic macrophages chronologically change their brain-entry routes and competence for neural progenitor-induced microglial differentiation
Mizuki Ono, Tsukasa Shimamura, Ziwei Yin, Takaki Miyata, Yuki Hattori
The paper shows that macrophages enter the developing mouse brain through different routes at different embryonic stages and that their ability to become microglia depends on their proximity to neural progenitors and TGF-β signaling.
bioRxiv · Oct 26, 2026 · PreprintDevelopmental Biology