Pharmacology & ToxicologyCancer LettersPeer-reviewed
REDD1 is a determinant of the sensitivity of renal cell carcinoma cells to autophagy inhibition that can be therapeutically exploited by targeting PIM kinase activity
Jennifer S. Carew, Claudia M. Espitia, Sruthi Sureshkumar…·Steffan T. Nawrocki
This paper identifies REDD1 as a key determinant of renal cell carcinoma sensitivity to autophagy inhibition and shows that PIM kinase inhibition enhances this sensitivity through REDD1 upregulation.
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