BioinformaticsbioRxivPreprint
Reconstruction of developmental landscapes by optimal-transport analysis of single-cell gene expression sheds light on cellular reprogramming.
Geoffrey R. Schiebinger, Jian Shu, Marcin Tabaka…·Eric S. Lander
Optimal transport converts a 65,781-cell reprogramming time course into probabilistic fates and trajectories, exposing alternative cell fates and a gene, Obox6, that improves reprogramming efficiency.