Justin Brumbaugh

Global Regulatory Functions of the Human CCR4-NOT Complex in mRNA Deadenylation and Decay

The paper identifies the regulatory roles of the CCR4-NOT complex in mRNA deadenylation and decay by analyzing transcriptome-wide effects of subunit depletion.

Attenuated estrogen signaling disrupts placentation and drives trophoblast defects in Down syndrome

This study identifies attenuated estrogen signaling and NRIP1 as key factors in trophoblast defects in Down syndrome using patient-derived stem cells.

Cleavage of histone H2A during embryonic stem cell differentiation destabilizes nucleosomes to counteract gene activation

The paper shows that cleavage of histone H2A by Cathepsin L during ESC differentiation reduces nucleosome stability and counteracts gene activation.

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

The paper profiles RNA content in P-bodies across vertebrate species, showing that RNA sequestration in condensates is linked to cell fate transitions through miRNA-dependent mechanisms.

Structure-guided design and development of cyclic peptide allosteric activators of Polycomb Repressive Complex 2

The paper designs a cyclic peptide that activates PRC2, leading to increased H3K27 trimethylation and improved stability in mice.

Reconstruction of developmental landscapes by optimal-transport analysis of single-cell gene expression sheds light on cellular reprogramming.

Optimal transport converts a 65,781-cell reprogramming time course into probabilistic fates and trajectories, exposing alternative cell fates and a gene, Obox6, that improves reprogramming efficiency.