GenomicsbioRxivPreprint
Fully T2T pedigree assemblies reveal genetic stability and epigenetic plasticity of human centromeres across inheritance and cell-fate transitions
Shihua Dong, Xiaoyun Xing, Monika Čechová…·Ting Wang
The paper uses fully phased telomere-to-telomere assemblies and long-read epigenomes to study centromere genetic and epigenetic dynamics across inheritance and cell-fate transitions, finding positional stability of CDRs and dynamic epigenetic changes.
DOI 10.64898/2026.02.14.705860