NeurosciencebioRxivPreprint
Intrastriatal delivery of a zinc finger protein targeting the mutant HTT gene by AAV9 obviates lipid phenotypes in brain and plasma of zQ175DN HD mice
Andrew Iwanowicz, Adel Boudi, Connor Seeley…·Kimberly B. Kegel-Gleason
The paper shows that reducing mutant HTT with a zinc finger protein in HD mice prevents lipid changes in brain and plasma.
DOI 10.1101/2025.01.06.630918