Lorenzo Merotto

The paper identifies six distinct tumor microenvironment niches in glioblastoma that correlate with patient survival and immunotherapy response.

Rectangle provides a scalable deconvolution framework for bulk RNA-seq using single-cell data, achieving high accuracy and robustness across diverse benchmarks.

This paper benchmarks second-generation single-cell-informed deconvolution tools for bulk RNA-seq, revealing performance differences based on data characteristics and providing an ecosystem called omnideconv.

This study identifies TLR3 as a conserved mediator of cardiac regeneration in zebrafish, showing its role in immune cell recruitment and DNA repair after myocardial injury.

SimBu simulates bulk RNA-seq data with variable cell type composition to create in silico gold standards for evaluating deconvolution methods.