Author

Adam Norton-Steele

University of OxfordORCID 0009-0006-1580-0117Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:imaging· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Felix ZhouiD· 2 shared Helen Mary ByrneiD· 2 shared Lewis MarshiD· 2 shared Xin LüiD· 2 shared Brittany‐Amber JacobsiD· 1 shared Carlos Ruiz PuigiD· 1 shared Heather A. HarringtoniD· 1 shared Heather Harrington· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

Felix ZhouORCID

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2 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedAug 17, 2026

Identifying phenotype-genotype-function coupling in 3D organoid imaging using Shape, Appearance and Motion Phenotype Observation Tool (SPOT)

Felix Zhou, Brittany‐Amber Jacobs, Adam Norton-Steele…·Xin Lü

The paper develops SPOT, a tool for analyzing 3D morpho-dynamics from 2D live-cell imaging, and applies it to organoids to identify phenotype-genotype-function relationships.

2 citations

mousehuman

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BioinformaticsbioRxivPreprintNov 28, 2025

Development of a universal imaging "phenome" using Shape, Appearance and Motion (SAM) features and the SAM Observation Tool (SPOT)

Felix Zhou, Adam Norton-Steele, Lewis Marsh…·Xin Lü

The paper develops a universal imaging phenome using SAM features and SPOT tool, showing it outperforms deep learning models in capturing dynamic cell behaviors.

DOI 10.1101/2025.11.28.691105

imagingstatistical model

𝕏 PostBluesky