Yves Paychère

CoPhaser models biological cycles in scRNA-seq by decomposing data into periodic and non-periodic sources, revealing insights into cell cycle dynamics and other periodic processes across diverse contexts.

This paper introduces scRitmo, a method to infer circadian phases and quantify biological desynchrony from single-cell transcriptomes, showing improved performance over existing methods.

This study shows that cell cycle inhibition in mouse gastruloids preserves core developmental processes but alters lineage proportions and differentiation timing.

CellSeg3D introduces self-supervised 3D cell segmentation models for fluorescence microscopy, achieving performance comparable to supervised methods without requiring ground truth labels.