Maxine Leonardi

Cell-cycle inhibition preserves robust development but rebalances lineages in mouse gastruloids

This study shows that cell cycle inhibition in mouse gastruloids preserves core developmental processes but alters lineage proportions and differentiation timing.

Statistical inference with a manifold-constrained RNA velocity model uncovers cell cycle speed modulations

This paper introduces a statistical RNA velocity model that improves dynamical consistency and inference of cell cycle speed from scRNA-seq data.

Cadherins modulate the self-organizing potential of gastruloids

This study identifies a Cadherin switch mechanism that regulates self-organization in gastruloids by linking pluripotency exit and cell differentiation.