Author

Sarah G. Aldous

UCL Queen Square Institute of NeurologyORCID 0009-0006-4600-6821Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Christian LandlesiD· 2 shared Edward J. SmithiD· 2 shared Georgina F OsborneiD· 2 shared Gillian P. BatesiD· 2 shared Iulia M NitaiD· 2 shared Jemima M PhillipsiD· 2 shared Jonathan R. Greene· 2 shared María Cañibano-PicoiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Christian LandlesORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 10, 2025

Lowering the HTT1a transcript as an effective therapy for Huntingtons disease

Aikaterini Smaragdi Papadopoulou, Julia F. Alterman, Christian Landles…·Gillian P. Bates

The paper shows that lowering HTT1a transcript levels delays molecular and neuropathological phenotypes in a Huntington's disease mouse model.

4 citations

mousebulk RNA-seq

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NeuroscienceBrainPeer-reviewedFeb 21, 2024

A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease

Sarah G. Aldous, Edward J. Smith, Christian Landles…·Gillian P. Bates

This study shows that reducing MSH3 in Huntington's disease mouse models prevents somatic CAG repeat expansion but does not accelerate disease onset, suggesting somatic expansion may not be required for pathogenesis.

63 citationstop 1%

mouseexperimental assay

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