Author

Emily M. Mahoney

Massachusetts Institute of TechnologyORCID 0009-0006-4862-5028Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1

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Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Assay:protein sequence· 1 Assay:protein structure· 1

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Michael T. LaubiD· 1 shared Peter C. DeWeirdtiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperMicrobiology

Michael T. LaubORCID

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1 paper

Recent·Most cited

MicrobiologySciencePeer-reviewedApr 2, 2026

✦ In-depth digest

DefensePredictor: A Machine Learning Model to Discover Novel Prokaryotic Immune Systems

Peter C. DeWeirdt, Emily M. Mahoney, Michael T. Laub

DefensePredictor combines ESM2 protein language model embeddings with genomic context features in a gradient boosting classifier to identify prokaryotic anti-phage defense genes, validating 45 previously unknown Escherichia coli systems.

44 citationstop 1%

E. colibacteria (other)

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